反应详情

1.9 g of 4-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one, 0.55 g of pyrrolidine, 0.85 g of ground sodium carbonate and 15 ml of absolute ethanol are heated at the boil for 2 hours, and the resulting hot solution is filtered and concentrated in vacuo. The obtained residue is dissolved in methylene chloride; the organic solution is washed at pH 7 with water and then concentrated; 1.4 g of 9,10-dihydro-4-(pyrrolidinoacetyl)-4H-thieno[3,4-b][1,5]benzodiazepin-10-one are thus obtained.

1. filtrationthe resulting hot solution is filtered
2. concentrationconcentrated in vacuo
3. dissolutionThe obtained residue is dissolved in methylene chloride
4. washthe organic solution is washed at pH 7 with water
5. concentrationconcentrated