HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 20503743, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 20063899 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 20503743 | HCID 20503743 | 90.3% |
Reaction Steps
1.9 g of 4-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one, 3.7 g of piperidine and 15 ml of dioxane are stirred at 80° C. for 1 hour; the resulting mixture is concentrated in vacuo, and the obtained residue is recrystallized from isopropanol/water. 2.0 g of 9,10-dihydro-4-(piperidinoacetyl)-4H-thieno[3,4-b][1,5]benzodiazepin-10-one are thus obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04381301 |
| Source dataset | uspto-grants-1983_04 |
| ORD ID | ord-b8c9ca64fcc84b4682643e931dc26971 |
| Source note | uspto-grants-1983_04 |