Piperidine → HCID 20503743, compound

HRID 1702446Notes

Reaction equation

HRID 1702446 reaction equation
Cl[CH2:2][C:3]([N:5]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[NH:9][C:8](=[O:16])[C:7]2=[CH:17][S:18][CH:19]=[C:6]12)=[O:4].[NH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>O1CCOCC1>[N:20]1([CH2:2][C:3]([N:5]2[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=3[NH:9][C:8](=[O:16])[C:7]3=[CH:17][S:18][CH:19]=[C:6]23)=[O:4])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 200638994-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one

Product 1

HCID 20503743HCID 20503743, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.9 g of 4-chloroacetyl-9,10-dihydro-4H-thieno[3,4-b][1,5]benzodiazepin-10-one, 3.7 g of piperidine and 15 ml of dioxane are stirred at 80° C. for 1 hour; the resulting mixture is concentrated in vacuo, and the obtained residue is recrystallized from isopropanol/water. 2.0 g of 9,10-dihydro-4-(piperidinoacetyl)-4H-thieno[3,4-b][1,5]benzodiazepin-10-one are thus obtained.

Workup

  1. concentrationthe resulting mixture is concentrated in vacuo
  2. customthe obtained residue is recrystallized from isopropanol/water

Sources & evidence

ORD record
ord-b8c9ca64fcc84b4682643e931dc26971
Source dataset
uspto-grants-1983_04
Patent number
US04381301

Reaction notes

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