Hydrochloric Acid → HCID 12923102, compound

HRID 1702589Notes

Reaction equation

HRID 1702589 reaction equation
Cl.[NH2:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)=[CH:10][CH:9]=2)[N:7]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24].O>N1C=CC=CC=1>[C:23]([NH:2][C:3]1[S:4][CH:5]=[C:6]([C:8]2[CH:9]=[CH:10][C:11]([O:14][CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)=[CH:12][CH:13]=2)[N:7]=1)(=[O:25])[CH3:24]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 7918Acetic AnhydrideHCID 12923100HCID 12923100, compound

Product 1

HCID 12923102HCID 12923102, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In 30 ml of pyridine was dissolved 2.0 g hydrochloride of 2-amino-4-[4-(4-chlorobenzyloxy)phenyl]thiazole, and 1.0 ml of acetic anhydride was added to the solution, followed by stirring at room temperature for 2 hours. Water was added and, the precipitating crystals were recovered by filtration, thus yielding 1.9 g (95.0%) of 2-acetylamino-4-[4-(4-chlorobenzyloxy)phenyl]thiazole. m.p., 239°-240° C.

Workup

  1. additionwas added to the solution
  2. filtrationthe precipitating crystals were recovered by filtration

Sources & evidence

ORD record
ord-fd4b5788943a497bae2b092a2fc96593
Source dataset
uspto-grants-1982_09
Patent number
US04348403

Reaction notes

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