Sodium Acetate → HCID 12923102, compound

HRID 1702591Notes

Reaction equation

HRID 1702591 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([CH2:6][O:7][C:8]2[CH:17]=[CH:16][C:11]([C:12](=O)[CH2:13]Cl)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:20]([NH:23][C:24]([NH2:26])=[S:25])(=[O:22])[CH3:21].C([O-])(=O)C.[Na+]>C(O)C>[C:20]([NH:23][C:24]1[S:25][CH:13]=[C:12]([C:11]2[CH:16]=[CH:17][C:8]([O:7][CH2:6][C:5]3[CH:18]=[CH:19][C:2]([Cl:1])=[CH:3][CH:4]=3)=[CH:9][CH:10]=2)[N:26]=1)(=[O:22])[CH3:21]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 2723593AcetylthioureaHCID 13050589HCID 13050589, compound

Product 1

HCID 12923102HCID 12923102, compoundYield 65.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 1.0 g portion of 4-(4-chlorobenzyloxy)phenacyl chloride, together with 440 mg of 1-acetylthiourea and 279 mg of sodium acetate, was stirred in 15 ml of ethanol under reflux for 2 hours. After cooling, the precipitated crystals were recovered by filtration, thus yielding 800 mg (65.6%) of 2-acetylamino-4-[4-(4-chlorobenzyloxy)phenyl]thiazole. m.p., 239°-240° C.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureAfter cooling
  3. filtrationthe precipitated crystals were recovered by filtration

Sources & evidence

ORD record
ord-5de4f27baf6a439794358f3d018bc890
Source dataset
uspto-grants-1982_09
Patent number
US04348403

Reaction notes

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