2,6-Difluorobenzoyl isocyanate → HCID 20526046, compound

HRID 1702597Notes

Reaction equation

HRID 1702597 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:16])([F:15])[CH:12]([F:14])[F:13])[NH2:6].[F:19][C:20]1[CH:30]=[CH:29][CH:28]=[C:27]([F:31])[C:21]=1[C:22]([N:24]=[C:25]=[O:26])=[O:23]>CCOCC>[F:1][C:2]([F:17])([F:18])[C:3]1[CH:4]=[C:5]([NH:6][C:25]([NH:24][C:22](=[O:23])[C:21]2[C:27]([F:31])=[CH:28][CH:29]=[CH:30][C:20]=2[F:19])=[O:26])[CH:7]=[CH:8][C:9]=1[O:10][C:11]([F:16])([F:15])[CH:12]([F:13])[F:14]

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 14011730HCID 14011730, compound

Product 1

HCID 20526046HCID 20526046, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

5.4 g of 3-trifluoromethyl-4-(1,1,2,2-tetrafluoroethoxy)-aniline are placed into 20 ml of abs. ether, and 3.7 g of 2,6-difluorobenzoylisocyanate dissolved in 10 ml of abs. ether are subsequently added dropwise at room temperature. The solid which has precipitated is filtered off with suction after 1 hour; it is then washed with abs. ether and dried in air. Recrystallisation from toluene yields N-[3-trifluoromethyl-4-(1,1,2,2-tetrafluoroethoxy)-phenyl]-N'-(2,6-difluorobenzoyl)-urea having a melting point of 182°-185° C.

Workup

  1. customThe solid which has precipitated
  2. filtrationis filtered off with suction after 1 hour
  3. washit is then washed with abs
  4. dry with materialether and dried in air
  5. customRecrystallisation from toluene

Sources & evidence

ORD record
ord-c67550d2163644ea8aeed3f526470a4d
Source dataset
uspto-grants-1982_09
Patent number
US04348412

Reaction notes

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