Thionyl Chloride → HCID 178479468, compound

Participants

Reaction Steps

A suspension of trans-4-guanidinomethylcyclohexanecarboxylic acid hydrochloride (1.2 g) and thionyl chloride (15 ml) was stirred at room temperature for 3 hours. Thereafter, excess thionyl chloride was removed by distillation under reduced pressure. The residue was washed with anhydrous ethyl ether to obtain trans-4-guanidinomethylcyclohexanecarboxylic acid chloride hydrochloride (1.2 g) as colorless powder.

Provenance & Evidence