Acetic Anhydride → 1-(3,4-Dihydroquinoxalin-1(2h)-yl)ethanone

HRID 1702620Notes

Reaction equation

HRID 1702620 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH2:3][CH2:2]1.[C:11](OC(=O)C)(=[O:13])[CH3:12]>C(O)C.O.[OH-].[Na+]>[C:11]([N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH2:3][CH2:2]1)(=[O:13])[CH3:12]

Participants

6

Reactant 2

HCID 7918Acetic AnhydrideHCID 770281,2,3,4-Tetrahydroquinoxaline

Product 1

HCID 2415071-(3,4-Dihydroquinoxalin-1(2h)-yl)ethanone

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

A solution of 0.186 mole (25 g) of 1,2,3,4-tetrahydroquinoxaline was dissolved in 250 ml of ethanol and 17.6 ml of acetic anhydride was added dropwise with stirring. The solution was then diluted with 750 ml of water and basified with 1 N sodium hydroxide. The solution was extracted with chloroform, the organic extracts were dried and then evaporated to provide the solid product, 1-acetyl-1,2,3,4-tetrahydroquinoxaline.

Workup

  1. extractionThe solution was extracted with chloroform
  2. customthe organic extracts were dried
  3. customevaporated

Sources & evidence

ORD record
ord-791de8ee2fcb4fa388e6ad72b420dc5d
Source dataset
uspto-grants-1982_09
Patent number
US04348521

Reaction notes

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