Acetic Anhydride → 1-(3,4-Dihydroquinoxalin-1(2h)-yl)ethanone

Participants

Reaction Steps

A solution of 0.186 mole (25 g) of 1,2,3,4-tetrahydroquinoxaline was dissolved in 250 ml of ethanol and 17.6 ml of acetic anhydride was added dropwise with stirring. The solution was then diluted with 750 ml of water and basified with 1 N sodium hydroxide. The solution was extracted with chloroform, the organic extracts were dried and then evaporated to provide the solid product, 1-acetyl-1,2,3,4-tetrahydroquinoxaline.

Provenance & Evidence