Acetic Anhydride → HCID 15580722, compound

HRID 1702647Notes

Reaction equation

HRID 1702647 reaction equation
[NH2:1][C:2]1[CH2:6][CH:5]([CH3:7])[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>CN(C)C1C=CN=CC=1.ClCCl>[CH3:7][CH:5]1[N:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:3]=[C:2]([NH:1][C:14](=[O:16])[CH3:15])[CH2:6]1

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 155806655-Methyl-1-phenyl-4,5-dihydro-1H-pyrazol-3-amine

Product 1

HCID 15580722HCID 15580722, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 6344DichloromethaneSolvent

Procedure

A mixture of 2.0 g. of 3-amino-5-methyl-1-phenyl-2-pyrazoline (prepared in Example 5), 5.0 ml. of acetic anhydride and 100 mg. of 4-dimethylaminopyridine is allowed to stand at room temperature for 3 hours. The mixture is filtered to give a white solid. The solid is dissolved in dichloromethane and is columnized and recrystallized as for Example 14 (B) to give 0.90 g. of the desired product as colorless plates, m.p. 144.5-146.5° C.

Workup

  1. additionA mixture of 2.0 g
  2. filtrationThe mixture is filtered
  3. customto give a white solid
  4. customto give 0.90 g

Sources & evidence

ORD record
ord-9ca8831bee114921bbe92dbfff95a0bd
Source dataset
uspto-grants-1982_09
Patent number
US04348527

Reaction notes

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