Hydrochloric Acid → HCID 20525803, compound

HRID 1702666Notes

Reaction equation

HRID 1702666 reaction equation
[CH2:1]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]([O:27]CC)=[O:26])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH-].[K+].C(O)C.O.Cl>O>[CH2:1]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([CH2:24][C:25]([OH:27])=[O:26])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 19096565Water ethanolHCID 54054771HCID 54054771, compound

Product 1

HCID 20525803HCID 20525803, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 6.0 g. of ethyl (4-hexadecylaminophenyl)acetate, 7.0 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is heated to reflux for 4 hours. While hot, the mixture is adjusted to pH 7 with conc. hydrochloric acid. The mixture is diluted with water cooled and filtered. Recrystallization of the precipitate yields (4-hexadecylaminophenyl)acetic acid.

Workup

  1. additionA mixture of 6.0 g
  2. temperatureto reflux for 4 hours
  3. temperaturecooled
  4. filtrationfiltered
  5. customRecrystallization of the precipitate

Sources & evidence

ORD record
ord-7874e915d97a48b2981d8de3e31744fd
Source dataset
uspto-grants-1982_09
Patent number
US04348399

Reaction notes

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