1-Bromohexadecane → HCID 53804060, compound

HRID 1702676Notes

Reaction equation

HRID 1702676 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](=[O:14])[C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.Br[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH3:31].C(=O)([O-])[O-].[K+].[K+].CN(C)P(N(C)C)(N(C)C)=O>O>[CH2:31]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9](=[O:14])[C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:7]=1)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH3:16]

Participants

6

Reactant 4

HCID 82131-BromohexadecaneHCID 11430Potassium CarbonateHCID 12679HexamethylphosphoramideHCID 11217770HCID 11217770, compound

Product 1

HCID 53804060HCID 53804060, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 0.10 mole of methyl p-aminophenylpyruvate, 0.10 mole of 1-bromohexadecane, and 0.10 mole of anhydrous potassium carbonate in 40 ml. of hexamethylphosphoramide is heated at 80° C. for 20 hrs. The mixture is then cooled, diluted with water and extracted with ether. The ethereal solution is then evaporated, yielding methyl (4-hexadecylaminophenyl)pyruvate.

Workup

  1. temperatureThe mixture is then cooled
  2. extractionextracted with ether
  3. customThe ethereal solution is then evaporated

Sources & evidence

ORD record
ord-8bcb2a82f1d841e4b235342ed5819c30
Source dataset
uspto-grants-1982_09
Patent number
US04348399

Reaction notes

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