Hydrochloric Acid → HCID 20525895, compound

HRID 1702695Notes

Reaction equation

HRID 1702695 reaction equation
[CH2:1]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[C:25][C:26]([NH2:28])=O)=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].Cl.S(Cl)(Cl)=O>>[CH2:1]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]#[C:25][C:26]#[N:28])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 20525823HCID 20525823, compound

Product 1

HCID 20525895HCID 20525895, compound

Procedure

As described in Example 33, a sample of 4-hexadecylaminophenylpropiolamide is treated successively with hydrogen chloride gas and refluxing thionyl chloride to afford 4-(hexadecylamino)phenylpropiolnitrile. Similarly prepared is 4-(4-hexadecylaminophenyl)butyronitrile.

Sources & evidence

ORD record
ord-26bfae0309384c4d818eb3dfd93bb781
Source dataset
uspto-grants-1982_09
Patent number
US04348399

Reaction notes

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