HRID1702702

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9934

未命名化合物

结构：CCCCCCCCCCCCCCCCNc1ccc(C=CC(=O)N2CSCC2C(=O)OCC)cc1

HCID54423945

未命名化合物

PRODUCTS

生成物

结构：CCCCCCCCCCCCCCCCNc1ccc(C=CC(=O)N2CSCC2C(=O)O)cc1

HCID53848543

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID86737261

未命名化合物

PROCEDURE

实验过程

By means of the alkaline hydrolysis method of Example 54, the ethyl ester of Example 51 is converted to the subject carboxylic acid. This acid is also prepared using the procedure of Example 51 except that the acylation of the thiazolidine-4-carboxylic acid is carried out in aqueous acetone sodium bicarbonate solution.

WORKUP

后处理

customBy means of the alkaline hydrolysis method of Example 54
customThis acid is also prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3276e6d51ce04e0f984c16c2e5bea113
来源数据集: uspto-grants-1982_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04348399
来源说明: uspto-grants-1982_09

反应 SMILES

[CH2:1]([NH:17][C:18]1[CH:37]=[CH:36][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([O:33]CC)=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:20][CH:19]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].S1CC(C(O)=O)NC1>C(=O)(O)[O-].[Na+].CC(C)=O>[CH2:1]([NH:17][C:18]1[CH:19]=[CH:20][C:21]([CH:22]=[CH:23][C:24]([N:26]2[CH:30]([C:31]([OH:33])=[O:32])[CH2:29][S:28][CH2:27]2)=[O:25])=[CH:36][CH:37]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]