P-Cresol → P-Cresol

HRID 1702754Notes

Reaction equation

HRID 1702754 reaction equation
[CH:1]1[C:6]([OH:7])=[CH:5][CH:4]=[C:3]([CH3:8])[CH:2]=1.[C:9](=[O:22])([O:16][CH2:17][C:18](F)(F)F)OCC(F)(F)F>C1(C)C=CC=CC=1.C[O-].[Na+]>[C:9](=[O:22])([O:16][C:17]1[CH:18]=[CH:4][C:3]([CH3:8])=[CH:2][CH:1]=1)[O:7][C:6]1[CH:5]=[CH:4][C:3]([CH3:8])=[CH:2][CH:1]=1.[CH:5]1[C:6]([OH:7])=[CH:1][CH:2]=[C:3]([CH3:8])[CH:4]=1

Participants

6

Reactant 2

HCID 2879P-CresolHCID 11447463Bis(2,2,2-trifluoroethyl) Carbonate

Product 2

HCID 2879P-CresolYield 86%HCID 221530Bis(4-methylphenyl) carbonate

Reagents, catalysts & solvents 2

HCID 10942334Sodium MethoxideCatalystHCID 1140TolueneSolvent

Procedure

p-Cresol (1.081 g.; 10 mmol.) was reacted with bis(2,2,2-trifluoroethyl) carbonate (1.37 g.; 6 mmol.) and sodium methoxide (2.7 mg.; 0.05 mmol.) in toluene, according to the general procedure of Example II. Bis(p-cresyl) carbonate was isolated by column chromatography in 70% yield (1.695 g.), along with unreacted p-cresol (0.310 g., 28%). ##STR8##

Sources & evidence

ORD record
ord-c89a25f2749f4ed7b128adba3caf4304
Source dataset
uspto-grants-1982_09
Patent number
US04349486

Reaction notes

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