Water → HCID 70474738, compound

HRID 1702760Notes

Reaction equation

HRID 1702760 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH2:6]([NH:8][C@@H:9]1[CH2:15][CH2:14][CH2:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C@H:10]1[OH:20])[CH3:7].C(N(CC)CC)C.O>C(Cl)Cl>[CH2:6]([N:8]([C@@H:9]1[CH2:15][CH2:14][CH2:13][C:12]2[CH:16]=[CH:17][CH:18]=[CH:19][C:11]=2[C@H:10]1[OH:20])[C:3](=[O:4])[CH2:2][Cl:1])[CH3:7]

Participants

6

Reactant 4

HCID 962WaterHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 70475151HCID 70475151, compound

Product 1

HCID 70474738HCID 70474738, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of 0.75 ml (0.022 m) of chloroacetyl chloride in 10 ml of methylene chloride was added dropwise to a solution of 2.3 g (0.0112 m) of trans-6-(N-ethylamino)-6,7,8,9-tetrahydro-5H-benzo cyclohepten-5-ol and 3.2 ml (0.023 m) of triethylamine in 90 ml of methylene chloride. The mixture was stirred 1/2 hour, water is added, and the layers are separated. The organic layer was dried over anhydrous sodium sulfate and concentrated to dryness in vacuo.

Workup

  1. customthe layers are separated
  2. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  3. concentrationconcentrated to dryness in vacuo

Sources & evidence

ORD record
ord-f8df2467c2064f43a554f1a0094d61ff
Source dataset
uspto-grants-1982_09
Patent number
US04349548

Reaction notes

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