Triethylamine → HCID 20525093, compound

HRID 1702780Notes

Reaction equation

HRID 1702780 reaction equation
[CH2:1]([N:4]([CH2:12][CH:13]=[CH2:14])[C:5]([CH2:7][CH2:8]C(O)=O)=[O:6])[CH:2]=[CH2:3].C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:22])C=CC=CC=1.C([N:34]([CH2:37]C)CC)C>C1C=CC=CC=1>[CH2:12]([N:4]([CH2:1][CH:2]=[CH2:3])[C:5]([CH2:7][CH2:8][N:34]=[C:37]=[O:22])=[O:6])[CH:13]=[CH2:14]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 199401P,P-Diphenylphosphinic azideHCID 20525038HCID 20525038, compound

Product 1

HCID 20525093HCID 20525093, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The reaction of 3-(N,N-diallylcarbamoyl)propionic acid and diphenylphosphoryl azide in a solution of triethyl amine and benzene provided a solution comprising 2-(N',N'-diallylcarbamoyl)ethyl isocyanate (I.R.: 2275 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-[2-(N',N'-diallylcarbamoyl)ethyl]carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 4.

Sources & evidence

ORD record
ord-7818da5c5b334c1fae76aa23b78e40d9
Source dataset
uspto-grants-1982_09
Patent number
US04349552

Reaction notes

Loading…