5-Fluorouracil → HCID 20525053, compound

HRID 1702781Notes

Reaction equation

HRID 1702781 reaction equation
O1CCN(C(CCC(O)=O)=O)CC1.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=O)C=CC=CC=1.[O:31]1[CH2:36][CH2:35][N:34]([C:37]([CH2:39][CH2:40][N:41]=[C:42]=[O:43])=[O:38])[CH2:33][CH2:32]1.[F:44][C:45]1[C:46](=[O:52])[NH:47][C:48](=[O:51])[NH:49][CH:50]=1>C1C=CC=CC=1.C(N(CC)CC)C>[O:31]1[CH2:32][CH2:33][N:34]([C:37]([CH2:39][CH2:40][NH:41][C:42]([N:49]2[CH:50]=[C:45]([F:44])[C:46](=[O:52])[NH:47][C:48]2=[O:51])=[O:43])=[O:38])[CH2:35][CH2:36]1

Participants

7

Reactant 4

HCID 33855-FluorouracilHCID 199401P,P-Diphenylphosphinic azideHCID 2253784-(Morpholin-4-yl)-4-oxobutanoic acidHCID 20525033HCID 20525033, compound

Product 1

HCID 20525053HCID 20525053, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 8471TriethylamineSolvent

Procedure

The reaction of 3-morpholinocarbonylpropionic acid and diphenylphosphoryl azide in a solution of triethyl amine and benzene provided a solution comprising 2-morpholinocarbonylethyl isocyanate, which was reacted with 5-fluorouracil to provide 1-[N-(2-morpholinocarbonylethyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 4.

Workup

  1. customprovided a solution

Sources & evidence

ORD record
ord-f89be985ad1d4b4881d9f734b778e709
Source dataset
uspto-grants-1982_09
Patent number
US04349552

Reaction notes

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