Hydrochloric Acid → HCID 20525070, compound

Participants

Reaction Steps

Hydrogen chloride gas was introduced to the solution of 1-[N-[3-(t-butoxycarbonylamino)propyl]carbamoyl]-5-fluorouracil (5.1 g.) which was prepared in Example 20 in ethanol (30 ml.) until precipitates were appeared for 1 hour with stirring under cooling with ice. The reaction mixture was further stirred for 1 hour at ambient temperature, and diethyl ether (100 ml.) was added therein. The resultant crystalline precipitates were collected by filtration and were dried over phosphoric anhydride to give 1-[N-(3-aminopropyl)carbamoyl]-5-fluorouracil hydrochloride (1.5 g.).

Provenance & Evidence