Hydrochloric Acid → HCID 20525070, compound

HRID 1702794Notes

Reaction equation

HRID 1702794 reaction equation
[ClH:1].C(OC([NH:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([N:16]1[CH:23]=[C:22]([F:24])[C:20](=[O:21])[NH:19][C:17]1=[O:18])=[O:15])=O)(C)(C)C>C(O)C>[ClH:1].[NH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([N:16]1[CH:23]=[C:22]([F:24])[C:20](=[O:21])[NH:19][C:17]1=[O:18])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20525037HCID 20525037, compound

Product 1

HCID 20525070HCID 20525070, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrogen chloride gas was introduced to the solution of 1-[N-[3-(t-butoxycarbonylamino)propyl]carbamoyl]-5-fluorouracil (5.1 g.) which was prepared in Example 20 in ethanol (30 ml.) until precipitates were appeared for 1 hour with stirring under cooling with ice. The reaction mixture was further stirred for 1 hour at ambient temperature, and diethyl ether (100 ml.) was added therein. The resultant crystalline precipitates were collected by filtration and were dried over phosphoric anhydride to give 1-[N-(3-aminopropyl)carbamoyl]-5-fluorouracil hydrochloride (1.5 g.).

Workup

  1. customuntil precipitates
  2. temperatureunder cooling with ice
  3. stirringThe reaction mixture was further stirred for 1 hour at ambient temperature
  4. additiondiethyl ether (100 ml.) was added
  5. customThe resultant crystalline precipitates
  6. filtrationwere collected by filtration
  7. dry with materialwere dried over phosphoric anhydride

Sources & evidence

ORD record
ord-7d3ced70ccde4ad9858aa0392fd45052
Source dataset
uspto-grants-1982_09
Patent number
US04349552

Reaction notes

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