HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-isocyanatobicyclo[2.2.1]heptane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Bicyclo[2.2.1]heptane-2-carboxylic acid | HCID 79113 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-isocyanatobicyclo[2.2.1]heptane | HCID 12614301 | — |
Reaction Steps
The reaction of 2-norbornanecarboxlic acid and diphenylphosphoryl azide in a solution of triethylamine and benzene provided a solution comprising 2-norbornyl isocyanate (I.R.: 2270 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-(2-norbornyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04349552 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-df0518687daa453099d1a903c1ce3618 |
| Source note | uspto-grants-1982_09 |