Triethylamine → 14370-47-9

HRID 1702798Notes

Reaction equation

HRID 1702798 reaction equation
[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2C(O)=O.C1(P(N=[N+]=[N-])(C2C=CC=CC=2)=[O:18])C=CC=CC=1.C([N:30]([CH2:33]C)CC)C>C1C=CC=CC=1>[CH:1]12[CH2:7][CH:4]([CH2:5][CH2:6]1)[CH2:3][CH:2]2[N:30]=[C:33]=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 79113Bicyclo[2.2.1]heptane-2-carboxylic acidHCID 199401P,P-Diphenylphosphinic azide

Product 1

HCID 1261430114370-47-9

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The reaction of 2-norbornanecarboxlic acid and diphenylphosphoryl azide in a solution of triethylamine and benzene provided a solution comprising 2-norbornyl isocyanate (I.R.: 2270 cm-1), which was reacted with 5-fluorouracil to provide 1-[N-(2-norbornyl)carbamoyl]-5-fluorouracil substantially in the similar method to that of Example 1.

Sources & evidence

ORD record
ord-df0518687daa453099d1a903c1ce3618
Source dataset
uspto-grants-1982_09
Patent number
US04349552

Reaction notes

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