反应详情

2-Chloro-3-methylquinoxaline (3.572 g., 0.02 mole) was dissolved in 50 ml. of methanol, treated with Norit and filtered. The filtrate was added to 3.767 g. (0.02 mole) of 1,3-dibutylthiourea dissolved in 25 ml. of methanol. The resulting solution was stirred at room temperature for 1 hour and evaporated on a rotary evaporator. The residual oil was triturated successively with several portions of ether, 2:1 pentane-ether and acetone, and was filtered and washed with pentane, to give 2.60 g. (38.6%) of product as a tan solid, m.p. 97°-99°.

1. filtrationfiltered
2. additionThe filtrate was added to 3.767 g
3. customevaporated on a rotary evaporator
4. customThe residual oil was triturated successively with several portions of ether, 2:1 pentane-ether and acetone
5. filtrationwas filtered
6. washwashed with pentane
7. customto give 2.60 g