反应详情

2-Chloro-3-quinoxalinecarboxylic acid ethyl ester (7.10 g., 0.03 mole) was dissolved in 125 ml. of acetone treated with Norit and filtered. The filtrate was added to 5.650 g. (0.03 mole) of 1,3-di-n-butylthiourea in 100 ml. of acetone. The solution was stirred at reflux under a nitrogen atmosphere for 6 hours, allowed to cool to room temperature, and stirred an additional 17 hours. The red solution was treated with Norit, filtered, and concentrated to a volume of 100 ml. The yellow solid that crystallized out was collected by filtration, washed and dried to give the 6.05 g. (47.5% yield) of product, m.p. 138°-139° C. (dec.).

1. filtrationfiltered
2. additionThe filtrate was added to 5.650 g
3. temperatureat reflux under a nitrogen atmosphere for 6 hours
4. stirringstirred an additional 17 hours
5. filtrationfiltered
6. concentrationconcentrated to a volume of 100 ml
7. customThe yellow solid that crystallized out
8. filtrationwas collected by filtration
9. washwashed
10. customdried
11. customto give the 6.05 g