Ammonia → HCID 20524091, compound

HRID 1702925Notes

Reaction equation

HRID 1702925 reaction equation
[C:1]([CH2:3][CH2:4][N:5]([CH2:7][CH2:8][CH2:9][C:10]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12][CH:11]=1)[CH3:6])#[N:2].N>[Ni].O1CCOCC1>[NH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:10]([CH2:9][CH2:8][CH2:7][N:5]([CH3:6])[CH2:4][CH2:3][CH2:1][NH2:2])=[CH:11]1

Participants

5

Reactant 2

HCID 222AmmoniaHCID 70545066HCID 70545066, compound

Product 1

HCID 20524091HCID 20524091, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 312751,4-DioxaneSolvent

Procedure

36.2 g N-(2-cyanoethyl)-N-methyl-3-(3-indolyl)propyl amine are hydrogenated at normal pressure and at room temperature with 20 g Raney-nickel catalyst in 400 ml dioxan and 400 ml of a 10% ammonia solution. N-[3-(3-indolyl)propyl]-N-methyl-1,3-diaminopropane is obtained after working up. M.pt of the neutral fumarate: 180°-181° (with decomposition) after crystallization from ethanol.

Sources & evidence

ORD record
ord-5bf41b3c07e2444abed959a2ee021fd7
Source dataset
uspto-grants-1982_09
Patent number
US04350634

Reaction notes

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