Hydrochloric Acid → HCID 67908176, compound

Temperature

20 °C

A mixture of 1 g of the product of Example 2, 8 ml of demineralized water and 0.8 ml of hydrochloric acid was stirred at 20° C. for one hour and was then heated at 60° C. for one hour and was cooled at 20° C. The mixture was diluted with 15 ml of water and was then extracted with methylene chloride. The organic phase was washed with aqueous N sodium hydroxide solution and with water until the wash water was neutral, dried and evaporated to dryness under reduced pressure. The residue was taken up in 10 ml of ether and a stream of hydrogen chloride was slowly bubbled therethrough. The mixture was vacuum filtered to obtain 350 mg of benzyl L-leucine hydrochloride melting at 135° C. and having a specific rotation of [α]D20 =-5.5°±1° (c=1% in 0.1 N hydrochloric acid). Circular Dichroism (dioxane): max. at 219 nm; Δε=+1.0.

1. temperaturewas then heated at 60° C. for one hour
2. temperaturewas cooled at 20° C
3. extractionwas then extracted with methylene chloride
4. washThe organic phase was washed with aqueous N sodium hydroxide solution and with water until the wash water
5. customdried
6. customevaporated to dryness under reduced pressure
7. customa stream of hydrogen chloride was slowly bubbled
8. filtrationfiltered

ORD record

ord-21d420eff18247d389c97da2dca27c1c

Source dataset

uspto-grants-1982_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04350637