Ammonia → 4(3H)-Quinazolinone, 3-amino-2-hydrazino-

HRID 1702979Notes

Reaction equation

HRID 1702979 reaction equation
Cl[C:2]1[N:11]=[C:10]([OH:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.O.[NH2:14][NH2:15].[NH3:16]>O>[NH2:16][N:11]1[C:10](=[O:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]1[NH:14][NH2:15]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 24654Hydrazine hydrate (1:1)HCID 178517815HCID 178517815, compound

Product 1

HCID 640574(3H)-Quinazolinone, 3-amino-2-hydrazino-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 134 g of the product of Step B and 670 ml of hydrazine hydrate was refluxed with stirring for about 5 hours until evolution of ammonia ceased and the mixture was cooled slightly and was diluted with 670 ml of water. The mixture was cooled to room temperature and was filtered and the product was rinsed with water and methanol and dried to obtain 101.5 of 3-amino-2-hydrazino-quinazolin-4(3H)-one.

Workup

  1. temperaturewas refluxed
  2. temperaturethe mixture was cooled slightly
  3. filtrationwas filtered
  4. washthe product was rinsed with water and methanol
  5. customdried

Sources & evidence

ORD record
ord-021658b6ce544c0c8061a5e51f515619
Source dataset
uspto-grants-1982_09
Patent number
US04350695

Reaction notes

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