Hydrazine hydrate (1:1) → HCID 20497519, compound

Participants

Reaction Steps

2-mercapto-3,6-dimethylquinazolin-4(3H)-one, 2-chloro-6-methylquinazolin-4-ol, 2-hydrazino-6-methylquinazolin-4-ol or 2-mercapto-6-methylquinazolin-4-ol was stirred in 5 volumes of hydrazine hydrate at reflux for 24 hours and the mixture was diluted with 5 volumes of water. The mixture was cooled to room temperature and was filtered. The product was washed with water and then methanol and dried to obtain a 95% yield of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one.

Provenance & Evidence