Hydrazine hydrate (1:1) → HCID 20497519, compound

HRID 1702980Notes

Reaction equation

HRID 1702980 reaction equation
SC1N(C)C(=O)C2C(=CC=C(C)C=2)[N:3]=1.ClC1N=C(O)C2C(=CC=C(C)C=2)N=1.[NH:28]([C:30]1[N:39]=[C:38]([OH:40])[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([CH3:41])[CH:36]=2)[N:31]=1)[NH2:29].SC1N=C(O)C2C(=CC=C(C)C=2)N=1.O.NN>O>[NH2:3][N:39]1[C:38](=[O:40])[C:37]2[C:32](=[CH:33][CH:34]=[C:35]([CH3:41])[CH:36]=2)[N:31]=[C:30]1[NH:28][NH2:29]

Participants

7

Reactant 5

HCID 24654Hydrazine hydrate (1:1)HCID 178423383HCID 178423383, compoundHCID 178423437HCID 178423437, compoundHCID 178423445HCID 178423445, compoundHCID 178423447HCID 178423447, compound

Product 1

HCID 20497519HCID 20497519, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-mercapto-3,6-dimethylquinazolin-4(3H)-one, 2-chloro-6-methylquinazolin-4-ol, 2-hydrazino-6-methylquinazolin-4-ol or 2-mercapto-6-methylquinazolin-4-ol was stirred in 5 volumes of hydrazine hydrate at reflux for 24 hours and the mixture was diluted with 5 volumes of water. The mixture was cooled to room temperature and was filtered. The product was washed with water and then methanol and dried to obtain a 95% yield of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one.

Workup

  1. temperatureat reflux for 24 hours
  2. filtrationwas filtered
  3. washThe product was washed with water
  4. dry with materialmethanol and dried

Sources & evidence

ORD record
ord-eebe994ffe734c2b84796ca6cb1e5426
Source dataset
uspto-grants-1982_09
Patent number
US04350695

Reaction notes

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