HCID 20497519, compound → HCID 20524256, compound

HRID 1702981Notes

Reaction equation

HRID 1702981 reaction equation
[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14]N>NCCCCO>[NH2:1][N:2]1[C:11](=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[N:4]=[C:3]1[NH:14][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]

Participants

3

Reactant 1

HCID 20497519HCID 20497519, compound

Product 1

HCID 20524256HCID 20524256, compoundYield 126.7%

Reagents, catalysts & solvents 1

HCID 258684-Amino-1-butanolSolvent

Procedure

20 g of 3-amino-2-hydrazino-6-methylquinazolin-4(3H)-one were stirred in 100 ml of 4-aminobutanol at 175° C. for 24 hours and the majority of the 4-aminobutanol was then distilled off under vacuum. The residue was diluted with water to crystallize out the product and the mixture was filtered. The product was washed and dried to obtain 16.2 g of 3-amino-2-(4-hydroxybutylamino)-6-methylquinazolin-4(3H)-one.

Workup

  1. distillationthe majority of the 4-aminobutanol was then distilled off under vacuum
  2. additionThe residue was diluted with water
  3. customto crystallize out the product
  4. filtrationthe mixture was filtered
  5. washThe product was washed
  6. customdried

Sources & evidence

ORD record
ord-e28a6e4f926c42078dcb238f07dd8c7b
Source dataset
uspto-grants-1982_09
Patent number
US04350695

Reaction notes

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