反应详情

700 g of methyl isonicotinate and 1.4 kg of methyl iodide were admixed in 2.0 liters of methanol and the resultant solution was stirred and refluxed for 5 hours. After cooling, the mixture was filtered off and the product was washed with ether and dried to obtain 1.385 kg of 4-methoxycarbonyl-1-methylpyridinium iodide (97.2% yield).

1. temperaturerefluxed for 5 hours
2. temperatureAfter cooling
3. filtrationthe mixture was filtered off
4. washthe product was washed with ether
5. customdried