Dichloromethane → N-methylspiro[indene-1,4'-piperidine]-3-carboxamide

HRID 170309Notes

Reaction equation

HRID 170309 reaction equation
[CH3:8][NH:9][C:10](=[O:11])[C:12]1=[CH:13][C:14]2([c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]31)[CH2:21][CH2:22][N:23]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:24][CH2:25]2.[Cl:33][CH2:34][Cl:35].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[CH3:8][NH:9][C:10](=[O:11])[C:12]1=[CH:13][C:14]2([c:15]3[cH:16][cH:17][cH:18][cH:19][c:20]31)[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]2

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59600600Tert-butyl 3-(methylcarbamoyl)spiro[indene-1,4'-piperidine]-1'-carboxylate

Product 1

HCID 59600609N-methylspiro[indene-1,4'-piperidine]-3-carboxamide

Sources & evidence

ORD record
ord-89dff6a2cc7540aba0612cf99a306308
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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