反应详情

温度

110 °C

A mixture of 18.2 g. of ethyl p-aminobenzoate 10.2 g. of sodium iodide, 10.0 g. of 5-phenylpentyl chloride and 60 ml. of hexamethylphosphoramide is stirred and heated at 110° C. in an oil bath for 20 hours. The mixture is chilled, diluted with 25 ml. of water and 25 ml. of ethanol, chilled and filtered. The solid is washed with 50 ml. of ethanol-water (1:1), with water and once with cold ethanol to give pale yellow crystals, m.p. 63°-64° C. Recrystallization from ethanol gives off-white crystals, m.p. 73°-75° C.

1. additionA mixture of 18.2 g
2. temperatureThe mixture is chilled
3. additiondiluted with 25 ml
4. filtrationfiltered
5. washThe solid is washed with 50 ml
6. customof ethanol-water (1:1), with water and once with cold ethanol to give pale yellow crystals, m.p. 63°-64° C
7. customRecrystallization from ethanol
8. customgives off-white crystals, m.p. 73°-75° C.