反应详情

A mixture of 7 g. of ethyl p-[(5-phenylpentyl)amino]benzoate (prepared as described in Example 46), 7 g. of potassium hydroxide and 100 ml. of ethanol-water (9:1) is refluxed for 3 hours. The mixture is acidified with concentrated hydrochloric acid while hot, diluted with water, cooled and filtered. The solid is washed with water to give white crystals, m.p. 141°-143° C. Recrystallization from ethanol gives white crystals, m.p. 142°-144° C.

1. additionA mixture of 7 g
2. temperaturecooled
3. filtrationfiltered
4. washThe solid is washed with water
5. customto give white crystals, m.p. 141°-143° C
6. customRecrystallization from ethanol
7. customgives white crystals, m.p. 142°-144° C.