反应详情

温度

110 °C

A mixture of 14.9 g. of ethyl p-aminobenzoate, 50 ml. of hexamethylphosphoramide, 10.1 g. of 8-phenyloctyl chloride and 6.75 g. of sodium iodide is stirred and heated in an oil bath at 110° C. for 24 hours. The mixture is chilled, diluted with 50 ml. of water and 25 ml. of ethanol, chilled and filtered. The solid is washed with ethanol-water (1:1) and with water to give crystals, m.p. 61°-68° C. Recrystallization from ethanol gives white crystals, m.p. 75°-76° C.

1. additionA mixture of 14.9 g
2. temperatureThe mixture is chilled
3. additiondiluted with 50 ml
4. filtrationfiltered
5. washThe solid is washed with ethanol-water (1:1) and with water
6. customto give crystals, m.p. 61°-68° C
7. customRecrystallization from ethanol
8. customgives white crystals, m.p. 75°-76° C.