反应详情

A mixture of 29.7 g. of crude ethyl 4-[2-(2-thienyl)ethylamino]benzoate, 29 g. of potassium hydroxide and 200 ml. of 95% ethanol is refluxed for 3 hours. The solution is diluted with 100 ml. of water and adjusted to pH 6 with concentrated hydrochloric acid. The mixture is cooled, filtered and the solid washed with ethanol-water (1:1) to give a solid. The solid is heated with 200 ml. of ethanol, filtered and the filtrate concentrated. Purification gives the product, m.p. 163°-165° C.

1. additionA mixture of 29.7 g
2. additionThe solution is diluted with 100 ml
3. temperatureThe mixture is cooled
4. filtrationfiltered
5. washthe solid washed with ethanol-water (1:1)
6. customto give a solid
7. temperatureThe solid is heated with 200 ml
8. filtrationof ethanol, filtered
9. concentrationthe filtrate concentrated
10. customPurification
11. customgives the product, m.p. 163°-165° C.