反应详情

A solution of 49.5 g. of ethyl 4-aminobenzoate, 34.9 g. of 3-(p-chlorophenyl)propanol O-mesylate in 100 ml. of hexamethylphosphoramide is heated at 125°-130° C. for 16 hours. The solution is diluted with 50 ml. of tetrahydrofuran and with 150 ml. of water. Chilling and filtering gives crystals which are washed with water and recrystallized from ethanol to give 28.3 g. of light yellow crystals. Recrystallizations give the product as crystals, m.p. 122°-124° C.

1. additionThe solution is diluted with 50 ml
2. temperatureChilling
3. filtrationfiltering
4. customgives crystals which
5. washare washed with water
6. customrecrystallized from ethanol
7. customto give 28.3 g
8. customRecrystallizations