HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(Thiazol-2-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-Bromothiazole | HCID 76430 | — |
| Solvent | 1-Methoxyethanol | HCID 3015637 | — |
| Product | 1-(Thiazol-2-yl)piperazine | HCID 911806 | 72.3% |
Reaction Steps
A mixture of piperazine (6.88 g) and 2-bromothiazole (2.28 g) in methoxyethanol (30 ml) was refluxed for 2.5 hr and evaporated. Water was added and the mixture was extracted with dichhloromethane. The extract was washed with water, dried over sodium sulfate and evaporated to give an oil (1.7 g) of 2-(1-piperazinyl)-thiazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04351832 |
| Source dataset | uspto-grants-1982_09 |
| ORD ID | ord-bdcce7ada0654cfe9ddbcc402e7bbb91 |
| Source note | uspto-grants-1982_09 |