Piperazine → 1-(Thiazol-2-yl)piperazine

HRID 1703183Notes

Reaction equation

HRID 1703183 reaction equation
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[C:8]1[S:9][CH:10]=[CH:11][N:12]=1>COC(O)C>[N:1]1([C:8]2[S:9][CH:10]=[CH:11][N:12]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 4837PiperazineHCID 764302-Bromothiazole

Product 1

HCID 9118061-(Thiazol-2-yl)piperazineYield 72.3%

Reagents, catalysts & solvents 1

HCID 30156371-MethoxyethanolSolvent

Procedure

A mixture of piperazine (6.88 g) and 2-bromothiazole (2.28 g) in methoxyethanol (30 ml) was refluxed for 2.5 hr and evaporated. Water was added and the mixture was extracted with dichhloromethane. The extract was washed with water, dried over sodium sulfate and evaporated to give an oil (1.7 g) of 2-(1-piperazinyl)-thiazole.

Workup

  1. temperaturewas refluxed for 2.5 hr
  2. customevaporated
  3. additionWater was added
  4. extractionthe mixture was extracted with dichhloromethane
  5. washThe extract was washed with water
  6. dry with materialdried over sodium sulfate
  7. customevaporated

Sources & evidence

ORD record
ord-bdcce7ada0654cfe9ddbcc402e7bbb91
Source dataset
uspto-grants-1982_09
Patent number
US04351832

Reaction notes

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