Tetrahydrofuran → HCID 86738578, compound

HRID 1703195Notes

Reaction equation

HRID 1703195 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][O:7][C@@H:8]1[CH2:30][CH2:29][C@@:28]2([CH3:31])[C@H:10]([C@@H:11]([O:33][CH2:34][O:35][CH2:36][CH2:37][O:38][CH3:39])[CH2:12][C@@H:13]3[C@@H:27]2[CH2:26][CH2:25][C@@:24]2([CH3:32])[C@H:14]3[CH2:15][CH2:16][C@@H:17]2[C@H:18]([CH3:23])[CH2:19][CH2:20][CH:21]=O)[CH2:9]1.O1C[CH2:43][CH2:42][CH2:41]1>>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][O:7][C@@H:8]1[CH2:30][CH2:29][C@@:28]2([CH3:31])[C@H:10]([C@@H:11]([O:33][CH2:34][O:35][CH2:36][CH2:37][O:38][CH3:39])[CH2:12][C@@H:13]3[C@@H:27]2[CH2:26][CH2:25][C@@:24]2([CH3:32])[C@H:14]3[CH2:15][CH2:16][C@@H:17]2[C@H:18]([CH3:23])[CH:19]=[CH:20][CH:21]=[C:42]([CH3:43])[CH3:41])[CH2:9]1

Participants

3

Reactant 2

HCID 8028TetrahydrofuranHCID 22821657HCID 22821657, compound

Product 1

HCID 86738578HCID 86738578, compound

Procedure

1.4 g of 3α,6α-bis(β-methoxyethoxymethoxy)-5β-cholan-24-al (prepared as described in my U.S. patent application Ser. No. 236,160) was dissolved in 5 ml of tetrahydrofuran, and this solution was added dropwise to the deep red ylid solution (as described in Example I), and the chain extension reaction carried out in the same manner as in Example I. The residue remaining after evaporation of petroleum ether was the 3α,6α-bis(β-methoxyethoxymethoxy)-5β-cholest-24-ene.

Workup

  1. additionthis solution was added dropwise to the deep red ylid solution (as described in Example I)
  2. customthe chain extension reaction
  3. customafter evaporation of petroleum ether

Sources & evidence

ORD record
ord-f4a2a3fead1e4a0196147abf39d55101
Source dataset
uspto-grants-1982_09
Patent number
US04351767

Reaction notes

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