Ethanol → 4-Hydroxybenzaldehyde

Participants

Reaction Steps

Sen et al J. Indian Chem. Soc. 9 173 (1932) state that the use of chloroform in an ethyl alcohol solution in the Reimer-Tiemann reaction increases the yield of aldehyde. However, the only example describing the reaction of phenol with chloroform and sodium hydroxide in aqueous ethyl alcohol shows a combined yield for salicylaldehyde and p-hydroxybenzaldehyde of only 33%, based on the phenol reacted. The proportion of salicylaldehyde to p-hydroxybenzaldehyde in the product is about five to one, the same as for the conventional aqueous reaction.

Provenance & Evidence