反应详情

A stirred solution containing 14.8 g (0.112 mole) of potassium phenoxide and 13.1 g (0.10 mole) of p-fluorochlorobenzene in 100 ml of N-methyl-2-pyrrolidinone is heated at reflux for a period of time necessary to effect complete reaction, as determined by vapor phase chromotography techniques. The crude reaction mixture is cooled and diluted to a volume of 400 ml with water, whereupon it is extracted with several portions of ether. The combined organic extracts are washed with a 5% sodium hydroxide solution, water, and a saturated sodium chloride solution, dried (magnesium sulfate), and concentrated in vacuo. Distillation at reduced pressure affords 11.1 g (54%) of material, b(0.05 mm) 73.5°-75.5°, whose spectral properties are in agreement with the desired structure.

1. temperatureis heated
2. temperatureat reflux for a period of time necessary
3. customreaction
4. customThe crude reaction mixture
5. temperatureis cooled
6. extractionis extracted with several portions of ether
7. washThe combined organic extracts are washed with a 5% sodium hydroxide solution, water
8. dry with materiala saturated sodium chloride solution, dried (magnesium sulfate)
9. concentrationconcentrated in vacuo
10. distillationDistillation at reduced pressure