Thiazole → HCID 178433298, compound

HRID 1703589Notes

Reaction equation

HRID 1703589 reaction equation
[N+:1]([CH:4]=[C:5](SC)[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])([O-:3])=[O:2].[S:19]1[CH:23]=[CH:22][N:21]=[CH:20]1>C(#N)C>[N+:1]([CH:4]=[C:5]([NH:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16])[NH:6][CH2:7][CH2:8][S:9][CH2:10][C:20]1[S:19][CH:23]=[CH:22][N:21]=1)([O-:3])=[O:2]

Participants

4

Reactant 2

HCID 9256ThiazoleHCID 178503826HCID 178503826, compound

Product 1

HCID 178433298HCID 178433298, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Reaction of 1-nitro-2-methylthio-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]ethylene with an excess of 2-[2-aminoethyl)thiomethyl]thiazole according to the procedure of Example 3, results in the production of 1-nitro-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]-2-[2-(2-thiazolylmethylthio)ethylamino]ethylene, m.p. 119°-120° (from acetonitrile). By the same procedure, reaction of 1-nitro-2-methylthio-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]ethylene with the following compounds

Sources & evidence

ORD record
ord-46ebaf0ee20e4e5da3d36e90eea01c8f
Source dataset
uspto-grants-1978_11
Patent number
US04124717

Reaction notes

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