2-(Bis(methylsulfanyl)methylidene)propanedinitrile → 1,1-Dicyano-2-[3-(2-oxazolylthio)propylamino]-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]ethylene
Reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][NH:5][C:6]=1[CH2:7][S:8][CH2:9][CH2:10][NH2:11].[C:12]([C:14]([C:20]#[N:21])=[C:15](SC)SC)#[N:13].[H-].NN.[NH2:25][CH2:26][CH2:27][CH2:28][S:29][C:30]1[O:31][CH:32]=[CH:33][N:34]=1.BrCCCC1C=CC=C2C(NC(=O)C=12)=O>>[C:12]([C:14]([C:20]#[N:21])=[C:15]([NH:25][CH2:26][CH2:27][CH2:28][S:29][C:30]1[O:31][CH:32]=[CH:33][N:34]=1)[NH:11][CH2:10][CH2:9][S:8][CH2:7][C:6]1[NH:5][CH:4]=[N:3][C:2]=1[CH3:1])#[N:13]Participants
6
Reactant 5
Product 1
Procedure
Reaction of 4-methyl-5-[(2-aminoethyl)thiomethyl]-imidazole with 1,1-dicyano-2,2-bis methylthioethylene by the procedure of Example 8(i) yields1,1-dicyano-2-methylthio-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]ethylene. (iii) Reaction of this methylthio compound with 2-(3-aminopropyl)thiooxazole by the procedure of Example 1(a) (ii) gives the title compound.
Sources & evidence
- ORD record
- ord-5f8a6f34366a4181a345d047136b8464
- Source dataset
- uspto-grants-1978_11
- Patent number
- US04124717
Reaction notes
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