Sodium Hydroxide → 5-Fluoro-1-((2-hydroxyethoxy)methyl)uracil

HRID 1703630Notes

Reaction equation

C([O:4][CH2:5][CH2:6][O:7][CH2:8][N:9]1[CH:16]=[C:15]([F:17])[C:13](=[O:14])[NH:12][C:10]1=[O:11])(=O)C.[OH-].[Na+]>>[OH:4][CH2:5][CH2:6][O:7][CH2:8][N:9]1[CH:16]=[C:15]([F:17])[C:13](=[O:14])[NH:12][C:10]1=[O:11]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 4443484HCID 4443484, compound

Product 1

HCID 723595-Fluoro-1-((2-hydroxyethoxy)methyl)uracil

Procedure

N1 -acetoxyethoxymethyl-5-fluorouracil was reacted with 1N NaOH for 1 hour at 40° C. to obtain N1 -2-hydroxyethoxymethyl-5-fluorouracil.

Sources & evidence

ORD record: ord-a9177509ab4f45b7a296b6b02cc16083
Source dataset: uspto-grants-1978_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04124765

Reaction notes

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