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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1703630Generated: October 31, 2026

Sodium Hydroxide → 5-Fluoro-1-((2-hydroxyethoxy)methyl)uracil

https://huagongshe.com/reaction/1703630

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium HydroxideHCID 14798—
Reactant2-((5-Fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)ethyl acetateHCID 4443484—
Product5-Fluoro-1-((2-hydroxyethoxy)methyl)uracilHCID 72359—

Reaction Steps

N1 -acetoxyethoxymethyl-5-fluorouracil was reacted with 1N NaOH for 1 hour at 40° C. to obtain N1 -2-hydroxyethoxymethyl-5-fluorouracil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04124765
Source datasetuspto-grants-1978_11
ORD IDord-a9177509ab4f45b7a296b6b02cc16083
Source noteuspto-grants-1978_11