反应详情

A mixture of methyl 1,2,4-triazole-3-carboxylate (12.7 g., 100 mmole) and 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (55.4 g., 110 mmole) was heated in an oil bath maintained at 160-165°. After the sugar had melted, bis(p-nitrophenyl) phosphate (400 mg.) was added with stirring and the mixture was heated under diminished pressure at 160-165° for 15-20 min. Crystallization of the residue from ethyl acetate-ethanol provided 42.5 g. (74.5%) of product with M.P. 137-139°.

1. temperaturewas heated in an oil bath
2. temperaturemaintained at 160-165°
3. temperaturethe mixture was heated under diminished pressure at 160-165° for 15-20 min
4. customCrystallization of the residue from ethyl acetate-ethanol
5. customprovided 42.5 g