HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → Taribavirin Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 1-(2,3,5-Tri-O-acetyl-beta-D-ribofuranosyl)-1H-1,2,4-triazole-3-carbonitrile | HCID 13456801 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | Taribavirin Hydrochloride | HCID 451447 | — |
Reaction Steps
A mixture of 3-cyano-1-(2,3,5-tri-O-acetyl-β -D-ribofuranosyl)-1,2,4-triazole (7.04 g., 20.0 mmole) ammonium chloride (1.07 g., 20.0 mmol) and anhydrous ammonia (150 ml.) was heated in a bomb at 85° for 18 hours. After removal of excess ammonia, the residue was crystallized from acetonitrile-ethanol to provide 5.30 g. (95%) of product with M.P. 177°-179° dec.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE029835 |
| Source dataset | uspto-grants-1978_11 |
| ORD ID | ord-9203cc9c20d445de9ecdcc8ad0a34a8c |
| Source note | uspto-grants-1978_11 |