反应详情

To a stirred mixture of 8g of 1[1-(4'-chloro[1,1']biphenyl-4-yl)ethyl]piperazine, 2.7g of sodium bicarbonate in 75 ml of absolute ethanol, add in a dropwise fashion 5.25g of cinnamyl bromide. Reflux the reaction mixture for 6 hours, concentrate in vacuo, and treat with 50 ml of 10% hydrochloric acid solution. Filter the dihydrochloride and recrystallize from 80% ethanol, m.p. 273°-275°. The free base has a melting point of 108°-109° after recrystallization from acetonitrile.

1. temperatureReflux the reaction mixture for 6 hours
2. concentrationconcentrate in vacuo
3. additiontreat with 50 ml of 10% hydrochloric acid solution
4. filtrationFilter the dihydrochloride
5. customrecrystallize from 80% ethanol, m.p. 273°-275°
6. customafter recrystallization from acetonitrile