1-(2-Hydroxyethyl)piperazine → HCID 22760361, compound

HRID 1703791Notes

Reaction equation

HRID 1703791 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([CH:14](Cl)[CH3:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[OH:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>O>[OH:17][CH2:18][CH2:19][N:20]1[CH2:25][CH2:24][N:23]([CH:14]([C:11]2[CH:12]=[CH:13][C:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)=[CH:9][CH:10]=2)[CH3:15])[CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 227603784-(1-Chloroethyl)-4'-fluoro-1,1'-biphenyl

Product 1

HCID 22760361HCID 22760361, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

With stirring, heat (on a steam bath) a mixture of 13g of 4'-fluoro-4-(1-chloroethyl)[1,1']biphenyl and 20g of 1-(2-hydroxyethyl piperazine for twenty hours. Treat the reaction mixture with 200 ml of water, filter and wash the solid with water to yield 1-(2-hydroxyethyl)-4-[1-(4'-fluoro[1,1']biphenyl-4-yl)ethyl]piperazine: m.p. 120°-123°. Recrystallize the product from acetonitrile, m.p. of 122°-123°.

Workup

  1. temperatureheat (on a steam bath)
  2. filtrationfilter
  3. washwash the solid with water

Sources & evidence

ORD record
ord-0098f55369c1476a898cb8c4029b3fb3
Source dataset
uspto-grants-1978_11
Patent number
US04125612

Reaction notes

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